Ritonavir or lopinavir/ritonavir drastically enhance plasma concentrations of oxycodone in healthful human volunteers because of inhibition of CYP3A4 and CYP2D6.[fifty eight] Rifampicin drastically reduces plasma concentrations of oxycodone because of robust induction of CYP3A4.Opioids for example oxycodone hydrochloride might impact the hypothalam

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